Abstract
A series of phenylbutene and butanol derivatives (6a-j, 12, 13, 15, 17, 24b,c, 26, 27a,b) were prepared from the readily available resorcinol derivatives 2a-f and 7-hydroxy-chroman (18). The products were tested for inhibitory activity on the LPS-induced TNF-alpha production in the plasma in comparison with that of cabenegrin A-I (1a).
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Benzene Derivatives / chemical synthesis*
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Benzene Derivatives / chemistry
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Benzene Derivatives / pharmacology
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Benzopyrans / chemical synthesis*
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Benzopyrans / chemistry
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Benzopyrans / pharmacology*
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Butanols / chemical synthesis*
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Butanols / chemistry
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Butanols / pharmacology
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Lipopolysaccharides / antagonists & inhibitors*
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Male
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Mice
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Mice, Inbred BALB C
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Structure-Activity Relationship
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Tumor Necrosis Factor-alpha / biosynthesis*
Substances
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Benzene Derivatives
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Benzopyrans
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Butanols
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Lipopolysaccharides
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Tumor Necrosis Factor-alpha