Temporary treatment with sirolimus and low-trough cyclosporine prevents acute islet allograft rejection, and combination with starch-conjugated deferoxamine promotes islet engraftment in the preclinical pig model

Transplant Proc. 2001 Feb-Mar;33(1-2):509. doi: 10.1016/s0041-1345(00)02114-x.

Authors

S Shibata¹, S Matsumoto, J Sageshima, K Hiraoka, D E Sutherland, N Kirchhof, Z Guo, K Koyama, T R Gilmore, M Dunning, J D Ansite, J D Shearer, S Clemmings, B E Hedlund, S N Sehgal, B J Hering

Affiliation

¹ Department of Surgery at University of Minnesota, Minneapolis, Minnesota, USA.

PMID: 11266930
DOI: 10.1016/s0041-1345(00)02114-x

No abstract available

MeSH terms

Acute Disease
Animals
Chelating Agents / therapeutic use*
Cyclosporine / therapeutic use
Deferoxamine / therapeutic use*
Drug Therapy, Combination
Graft Rejection / prevention & control*
Graft Survival / drug effects*
Immunosuppressive Agents / therapeutic use*
Islets of Langerhans Transplantation / immunology*
Sirolimus / therapeutic use
Swine
Transplantation, Homologous

Substances

Chelating Agents
Immunosuppressive Agents
Cyclosporine
Deferoxamine
Sirolimus