[All-trans retinoic acid combined with low-dose cytosine arabinoside treatment for acute myelogenous leukemia with trilineage myelodysplasia--a case report]

N Maeda; S Satake; Y Okada; S Asahara; N Hasuike; M Tamura; M Takata; K Tasaka; T Okutani; Y Maeda; Y Tomofuji; T Chinzei; K Saigo

[All-trans retinoic acid combined with low-dose cytosine arabinoside treatment for acute myelogenous leukemia with trilineage myelodysplasia--a case report]

Gan To Kagaku Ryoho. 2001 Mar;28(3):407-10.

[Article in Japanese]

Authors

N Maeda¹, S Satake, Y Okada, S Asahara, N Hasuike, M Tamura, M Takata, K Tasaka, T Okutani, Y Maeda, Y Tomofuji, T Chinzei, K Saigo

Affiliation

¹ Dept. of Internal Medicine, Kakogawa Municipal Hospital.

PMID: 11265415

Abstract

AML with trilineage myelodysplasia (AML/TMDS) is recognized as having of poor prognosis due to its resistance to chemotherapy in comparison with de novo AML. An AML/TMDS patient who failed to respond to ordinary induction therapy achieved complete remission with combination therapy consisting of all-trans retinoic acid (ATRA) and low-dose Ara-C. No serious toxicity was observed. ATRA combined with low-dose Ara-C could be an alternative treatment for this kind of patient.

Publication types

Case Reports
English Abstract

MeSH terms

Antimetabolites, Antineoplastic / administration & dosage
Antineoplastic Agents / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Cytarabine / administration & dosage
Female
Humans
Leukemia, Myeloid, Acute / complications*
Leukemia, Myeloid, Acute / drug therapy*
Middle Aged
Neural Tube Defects / complications
Neural Tube Defects / drug therapy*
Tretinoin / administration & dosage

Substances

Antimetabolites, Antineoplastic
Antineoplastic Agents
Cytarabine
Tretinoin