Versatile synthons for optically pure alpha-amino aldehydes and alpha-amino acids: (+)- and (-)-4,5-dialkoxy-2-oxazolidinones

T Morita; Y Nagasawa; S Yahiro; H Matsunaga; T Kunieda

doi:10.1021/ol015535r

Versatile synthons for optically pure alpha-amino aldehydes and alpha-amino acids: (+)- and (-)-4,5-dialkoxy-2-oxazolidinones

Org Lett. 2001 Mar 22;3(6):897-9. doi: 10.1021/ol015535r.

Authors

T Morita¹, Y Nagasawa, S Yahiro, H Matsunaga, T Kunieda

Affiliation

¹ Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.

PMID: 11263910
DOI: 10.1021/ol015535r

Abstract

Both enantiomers of trans-5-benzyloxy-4-methoxy- (BMOx) and trans-4,5-dimethoxy-2-oxazolidinones (DMOx), which are readily accessible from simple 2-oxazolone heterocycles, represent good candidates for a new class of chiral synthons for use in the preparation of optically pure alpha-amino aldehydes and alpha-amino acids, respectively.

MeSH terms

Aldehydes / chemical synthesis*
Aldehydes / chemistry
Amines / chemical synthesis*
Amines / chemistry
Amino Acids / chemical synthesis*
Amino Acids / chemistry
Indicators and Reagents
Molecular Conformation
Molecular Structure
Oxazolidinones / chemical synthesis*
Oxazolidinones / chemistry
Stereoisomerism

Substances

Aldehydes
Amines
Amino Acids
Indicators and Reagents
Oxazolidinones