Saponins from the roots of Zygophyllum gaetulum and their effects on electrically-stimulated guinea-pig ileum

Phytochemistry. 2001 Feb;56(4):393-8. doi: 10.1016/s0031-9422(00)00415-5.

Abstract

A new ursanolide, 3beta-O-alpha-L-rhamnopyranosyl-(1->2)-O-alpha-L-arabinopyranosyl-(1->2)-beta-D-glucopyranosyl)oxy]-ursan-20beta,28-olide, zygophyloside N (1), and three known quinovic acid glycosides were isolated from the methanolic extract of the roots of Zygophyllum gaetulum. The crude extract, some fractions and 3-O-beta-D-glucopyranosyl quinovic acid 28-beta-D-glucopyranosyl ester, significantly and dose-dependently, are able to reduce the electrically-induced contractions of isolated guinea-pig ileum. The structure of compound (1) was determined, using 1D and 2D NMR techniques.

MeSH terms

  • Animals
  • Carbohydrate Sequence
  • Electric Stimulation
  • Guinea Pigs
  • Ileum / drug effects
  • Ileum / physiology
  • In Vitro Techniques
  • Magnetic Resonance Spectroscopy
  • Male
  • Molecular Sequence Data
  • Morocco
  • Muscle Contraction / drug effects
  • Muscle, Smooth / drug effects
  • Muscle, Smooth / physiology
  • Parasympatholytics / chemistry
  • Parasympatholytics / isolation & purification*
  • Parasympatholytics / pharmacology
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Saponins / pharmacology
  • Triterpenes*

Substances

  • 3-O-rhamnopyranosyl-(1-2)-O-arabinopyranosyl-(1-2)-glucopyranosyl-oxy-ursan-20,28-olide
  • Parasympatholytics
  • Saponins
  • Triterpenes