Abstract
A new ursanolide, 3beta-O-alpha-L-rhamnopyranosyl-(1->2)-O-alpha-L-arabinopyranosyl-(1->2)-beta-D-glucopyranosyl)oxy]-ursan-20beta,28-olide, zygophyloside N (1), and three known quinovic acid glycosides were isolated from the methanolic extract of the roots of Zygophyllum gaetulum. The crude extract, some fractions and 3-O-beta-D-glucopyranosyl quinovic acid 28-beta-D-glucopyranosyl ester, significantly and dose-dependently, are able to reduce the electrically-induced contractions of isolated guinea-pig ileum. The structure of compound (1) was determined, using 1D and 2D NMR techniques.
MeSH terms
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Animals
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Carbohydrate Sequence
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Electric Stimulation
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Guinea Pigs
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Ileum / drug effects
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Ileum / physiology
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Male
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Molecular Sequence Data
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Morocco
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects
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Muscle, Smooth / physiology
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Parasympatholytics / chemistry
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Parasympatholytics / isolation & purification*
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Parasympatholytics / pharmacology
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology
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Triterpenes*
Substances
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3-O-rhamnopyranosyl-(1-2)-O-arabinopyranosyl-(1-2)-glucopyranosyl-oxy-ursan-20,28-olide
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Parasympatholytics
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Saponins
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Triterpenes