[Inhibitory effect of matrine on lipopolysacchride-induced tumor necrosis factor and interleukin-6 production from rat Kupffer cells]

Yao Xue Xue Bao. 1997;32(2):93-6.
[Article in Chinese]

Abstract

The effect of matrine on the lipopolysacchride (LPS)-induced tumor necrosis factor and interleukin-6 production from rat Kupffer cell was investigated. Results showed that matrine 125, 250 and 500 mg.L-1 suppressed TNF and IL-6 production from Cal-primed Kupffer cells in the presence of lipopolysacchrides (LPS, 100 micrograms.L-1) in a concentration-dependent manner. Treatment with matrine 50 and 100 mg.kg-1 before LPS injection(3.5 mg.kg-1) markedly decreased mouse serum TNF and IL-6. The results suggest that matrine may have protective effect on LPS-induced liver injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / pharmacology*
  • Animals
  • Female
  • Interleukin-6 / blood
  • Interleukin-6 / metabolism*
  • Kupffer Cells / metabolism*
  • Lipopolysaccharides
  • Matrines
  • Mice
  • Mice, Inbred ICR
  • Quinolizines
  • Rats
  • Rats, Wistar
  • Tumor Necrosis Factor-alpha / metabolism*

Substances

  • Alkaloids
  • Interleukin-6
  • Lipopolysaccharides
  • Quinolizines
  • Tumor Necrosis Factor-alpha
  • Matrines