Abstract
G(12) heterotrimeric G proteins transduce signals from a number of receptors involved in the regulation of cardiovascular function. Recently, it has been discovered that these G proteins regulate the activity of Bruton's tyrosine kinase and Ras-GAP1(m) through a conserved PH-BM domain. These findings provide new insights into the signaling pathways initiated by G(12), which regulate cytoskeletal organization, cell proliferation and cardiovascular function.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Agammaglobulinaemia Tyrosine Kinase
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GTP-Binding Protein alpha Subunits, G12-G13
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Heterotrimeric GTP-Binding Proteins / metabolism*
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Humans
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Protein-Tyrosine Kinases / metabolism*
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Signal Transduction*
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ras GTPase-Activating Proteins / metabolism*
Substances
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ras GTPase-Activating Proteins
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Protein-Tyrosine Kinases
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Agammaglobulinaemia Tyrosine Kinase
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GTP-Binding Protein alpha Subunits, G12-G13
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Heterotrimeric GTP-Binding Proteins