Signaling of G(alpha)(12) family of G proteins through a tyrosine kinase and a Ras-GAP

Trends Cardiovasc Med. 2000 May;10(4):160-5. doi: 10.1016/s1050-1738(00)00054-2.

Abstract

G(12) heterotrimeric G proteins transduce signals from a number of receptors involved in the regulation of cardiovascular function. Recently, it has been discovered that these G proteins regulate the activity of Bruton's tyrosine kinase and Ras-GAP1(m) through a conserved PH-BM domain. These findings provide new insights into the signaling pathways initiated by G(12), which regulate cytoskeletal organization, cell proliferation and cardiovascular function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Agammaglobulinaemia Tyrosine Kinase
  • GTP-Binding Protein alpha Subunits, G12-G13
  • Heterotrimeric GTP-Binding Proteins / metabolism*
  • Humans
  • Protein-Tyrosine Kinases / metabolism*
  • Signal Transduction*
  • ras GTPase-Activating Proteins / metabolism*

Substances

  • ras GTPase-Activating Proteins
  • Protein-Tyrosine Kinases
  • Agammaglobulinaemia Tyrosine Kinase
  • GTP-Binding Protein alpha Subunits, G12-G13
  • Heterotrimeric GTP-Binding Proteins