Synthesis and antiviral activity of novel D- and L-2'-azido-2',3'-dideoxyribofuranosyl-4'-thiopyrimidines and purines

H O Kim; Y H Kim; H Suh; L S Jeong

doi:10.1016/s0960-894x(01)00006-3

Synthesis and antiviral activity of novel D- and L-2'-azido-2',3'-dideoxyribofuranosyl-4'-thiopyrimidines and purines

Bioorg Med Chem Lett. 2001 Feb 26;11(4):599-603. doi: 10.1016/s0960-894x(01)00006-3.

Authors

H O Kim¹, Y H Kim, H Suh, L S Jeong

Affiliation

¹ College of Medicine, Yonsei University, Seoul, South Korea.

PMID: 11229780
DOI: 10.1016/s0960-894x(01)00006-3

Abstract

Novel D- and L-2'-azido-2',3'-dideoxyribofuranosyl-4'-thiopyrimidines and purines have been synthesized starting from L-xylose and D-xylose, respectively. Among synthesized compounds tested against several viruses such as HIV-1, HSV-1, HSV-2, and HCMV, D-beta-N6-methyladenine (ent-22a) and D-alpha-N6-methyladenine (ent-22b) analogues were found to exhibit significant anti-HCMV activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemical synthesis*
Antiviral Agents / pharmacology
Thionucleosides / chemical synthesis*
Thionucleosides / pharmacology

Substances

Antiviral Agents
Thionucleosides