Abstract
Female CBA mice were injected with s.c. synthetic tetrapeptide Epithalon from a 6-month age until death. The drug failed to affect the body weight or food consumption, physical activity or behavioural parameters. However, it slowed down the age-related switching off of the estrus function, decreased body temperature, decelerated free redical processes, prolonged the mice life span with an accompanying drop in spontaneous tumour incidence.
MeSH terms
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Aging / physiology*
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Animals
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Body Temperature / drug effects
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Body Weight / drug effects
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Eating / drug effects
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Estrus / drug effects
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Female
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Free Radicals / metabolism
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Longevity / drug effects*
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Mice
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Mice, Inbred CBA
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Motor Activity / drug effects
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Muscle Fatigue / drug effects
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Neoplasms / prevention & control
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Oligopeptides / pharmacology*
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Reproduction / drug effects
Substances
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Free Radicals
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Oligopeptides
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alanyl-glutamyl-aspartyl-glycine