A flow injection chemiluminescence system for the determination of isoniazid

Fresenius J Anal Chem. 2000 Oct;368(4):429-31. doi: 10.1007/s002160000473.

Abstract

A chemiluminescence (CL) flow system is described for the determination of isoniazid based on its enhancement on the chemiluminescence (CL) emission produced upon mixing a hexacyanoferrate(III) solution with an alkaline luminol solution. The system responds linearly to isoniazid concentration in the range 0-1 mg/L with a detection limit (3sigma) of 0.03 microg/L, relative standard deviation (RSD) of 1.2% for 0.1 mg/L isoniazid (n = 11). The system has been successfully applied to the determination of isoniazid in pharmaceutical preparations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / analysis*
  • Antitubercular Agents / standards
  • Isoniazid / analysis*
  • Isoniazid / standards
  • Luminescent Measurements
  • Pharmaceutical Preparations / analysis
  • Pharmaceutical Preparations / standards
  • Reference Standards
  • Sensitivity and Specificity
  • Tablets / analysis

Substances

  • Antitubercular Agents
  • Pharmaceutical Preparations
  • Tablets
  • Isoniazid