Abstract
Many spices, including plants of the ginger family, possess anticarcinogenic activity. However, the molecular mechanisms by which they exert their antitumorigenic effects are unknown. Activator protein 1 (AP-1) has a critical role in tumor promotion, and blocking of tumor promoter-induced activation of AP-1 inhibits neoplastic transformation. Epidermal growth factor induces cell transformation and AP-1 activity. The purpose of this study was to investigate the effect of two structurally related compounds of the ginger family, [6]-gingerol and [6]-paradol, on EGF-induced cell transformation and AP-1 activation. Our results provide the first evidence that both block EGF-induced cell transformation but act by different mechanisms.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticarcinogenic Agents / pharmacology*
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Catechols
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Cell Death / drug effects
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Cell Line
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Cell Transformation, Neoplastic / chemically induced
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Cell Transformation, Neoplastic / drug effects*
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DNA / metabolism
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Enzyme Induction / drug effects
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Epidermal Cells
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Epidermal Growth Factor / antagonists & inhibitors*
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Epidermis / drug effects
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Fatty Alcohols / pharmacology*
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Guaiacol / analogs & derivatives
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Guaiacol / pharmacology
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Ketones / pharmacology
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Mice
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Mitogen-Activated Protein Kinases / metabolism
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Phosphorylation / drug effects
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Plants, Medicinal
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Transcription Factor AP-1 / metabolism*
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p38 Mitogen-Activated Protein Kinases
Substances
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Anticarcinogenic Agents
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Catechols
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Fatty Alcohols
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Ketones
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Transcription Factor AP-1
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Epidermal Growth Factor
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Guaiacol
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DNA
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gingerol
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6-paradol
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Mitogen-Activated Protein Kinases
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p38 Mitogen-Activated Protein Kinases