The authors studied solitary and combined effects of vinyl chloride and dichloroethane in chronic (4 months) inhalation experiment using concentrations of 50 and 500 mg/m3. The experiment revealed general toxic effects including disorders of central nervous system and liver. Those disorders are caused by reductive-oxidative reactions disturbances and dystrophic processes. The authors determined safe combinations of vinyl chloride and dichloroethane concentrations for associated action.