Symptom profiles in children with ADHD: effects of comorbidity and gender

J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):137-46. doi: 10.1097/00004583-200102000-00008.

Abstract

Objective: To examine ratings and objective measures of attention-deficit/hyperactivity disorder (ADHD) symptoms to assess whether ADHD children with and without comorbid conditions have equally high levels of core symptoms and whether symptom profiles differ as a function of comorbidity and gender.

Method: Four hundred ninety-eight children from the NIMH Collaborative Multisite Multimodal Treatment Study of Children With Attention-Deficit/Hyperactivity Disorder (MTA) were divided into comorbid groups based on the parent Diagnostic Interview Schedule for Children and assessed via parents' and teachers' Swanson, Nolan, and Pelham (SNAP) ratings and a continuous performance test (CPT). Comorbidity and gender effects were examined using analyses of covariance controlled for age and site.

Results: CPT inattention, impulsivity, and dyscontrol errors were high in all ADHD groups. Children with ADHD + oppositional defiant or conduct disorder were rated as more impulsive than inattentive, while children with ADHD + anxiety disorders (ANX) were relatively more inattentive than impulsive. Girls were less impaired than boys on most ratings and several CPT indices, particularly impulsivity, and girls with ADHD + ANX made fewer CPT impulsivity errors than girls with ADHD-only.

Conclusions: Children with ADHD have high levels of core symptoms as measured by rating scales and CPT, irrespective of comorbidity. However, there are important differences in symptomatology as a function of comorbidity and gender.

Publication types

  • Multicenter Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Analysis of Variance
  • Anxiety Disorders / epidemiology*
  • Attention Deficit Disorder with Hyperactivity / epidemiology
  • Attention Deficit and Disruptive Behavior Disorders / epidemiology*
  • Child
  • Comorbidity
  • Conduct Disorder / epidemiology
  • Female
  • Humans
  • Male
  • North America / epidemiology
  • Risk Factors
  • Sex Factors