Antimycobacterial in vitro activity of cobalt(II) isonicotinoylhydrazone complexes. Part 10

Bioorg Med Chem Lett. 2001 Feb 12;11(3):301-3. doi: 10.1016/s0960-894x(00)00648-x.

Abstract

Octahedral cobalt(II) complexes of isonicotinoylhydrazones, which were obtained from the primary antituberculous agent isoniazid, have been synthesised and characterised. Their antimycobacterial in vitro activity has been evaluated against Mycobacterium tuberculosis H37Rv: they exhibit MIC values ranging from < 0.1 to 0.39 microg/mL, showing them to be generally more active than previously reported analogous Cu(II) and Ni(II) complexes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antitubercular Agents / chemical synthesis*
  • Antitubercular Agents / pharmacology
  • Cell Division / drug effects
  • Chlorocebus aethiops
  • Cobalt / chemistry
  • Combinatorial Chemistry Techniques
  • Drug Stability
  • Ligands
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / drug effects
  • Organometallic Compounds / chemical synthesis
  • Organometallic Compounds / pharmacology*
  • Structure-Activity Relationship
  • Vero Cells

Substances

  • Antitubercular Agents
  • Ligands
  • Organometallic Compounds
  • Cobalt