(1-oxo-2-substituted-5-indanyloxy)acetic acids, a new class of potent renal agents possessing both uricosuric and saluretic activity. A reexamination of the role of sulfhydryl binding in the mode of action of acylphenoxyacetic acidsaluretics

J Med Chem. 1975 Feb;18(2):225-8. doi: 10.1021/jm00236a031.
No abstract available

MeSH terms

  • Acetates / chemical synthesis
  • Animals
  • Chlorides / urine
  • Diuresis / drug effects
  • Diuretics / chemical synthesis*
  • Diuretics / pharmacology
  • Dogs
  • Female
  • Glycolates / chemical synthesis
  • Glycolates / pharmacology
  • Indans / chemical synthesis*
  • Indans / pharmacology
  • Indenes / chemical synthesis*
  • Male
  • Pan troglodytes
  • Potassium / urine
  • Rats
  • Sodium / urine
  • Stereoisomerism
  • Structure-Activity Relationship
  • Uricosuric Agents / chemical synthesis*
  • Uricosuric Agents / pharmacology

Substances

  • Acetates
  • Chlorides
  • Diuretics
  • Glycolates
  • Indans
  • Indenes
  • Uricosuric Agents
  • Sodium
  • Potassium