Synthesis and evaluation of caffeic acid amides as antioxidants

P Rajan; I Vedernikova; P Cos; D V Berghe; K Augustyns; A Haemers

doi:10.1016/s0960-894x(00)00630-2

Synthesis and evaluation of caffeic acid amides as antioxidants

Bioorg Med Chem Lett. 2001 Jan 22;11(2):215-7. doi: 10.1016/s0960-894x(00)00630-2.

Authors

P Rajan¹, I Vedernikova, P Cos, D V Berghe, K Augustyns, A Haemers

Affiliation

¹ Department of Medicinal Chemistry, University of Antwerpen (UIA), Belgium.

PMID: 11206462
DOI: 10.1016/s0960-894x(00)00630-2

Abstract

A series of amides of caffeic acid has been synthesised and their antioxidant properties evaluated as lipid peroxidation inhibitors. Anilides of caffeic acid were found to be very efficient antioxidants with IC50's of 0.3 microM.

MeSH terms

Amides / chemical synthesis
Amides / pharmacology
Anilides / chemical synthesis
Anilides / pharmacology
Antioxidants / chemical synthesis*
Antioxidants / pharmacology
Caffeic Acids / chemical synthesis
Caffeic Acids / pharmacology*
Combinatorial Chemistry Techniques
Free Radicals / chemical synthesis
Free Radicals / chemistry
Hydrogen Bonding
Inhibitory Concentration 50
Lipid Peroxidation / drug effects
Molecular Conformation
Structure-Activity Relationship

Substances

Amides
Anilides
Antioxidants
Caffeic Acids
Free Radicals