Chemical synthesis of UDP-beta-L-arabinofuranose and its turnover to UDP-beta-L-arabinopyranose by UDP-galactopyranose mutase

Q Zhang; H W Liu

doi:10.1016/s0960-894x(00)00616-8

Chemical synthesis of UDP-beta-L-arabinofuranose and its turnover to UDP-beta-L-arabinopyranose by UDP-galactopyranose mutase

Bioorg Med Chem Lett. 2001 Jan 22;11(2):145-9. doi: 10.1016/s0960-894x(00)00616-8.

Authors

Q Zhang¹, H W Liu

Affiliation

¹ Department of Chemistry, University of Minnesota, Minneapolis 55455, USA.

PMID: 11206446
DOI: 10.1016/s0960-894x(00)00616-8

Abstract

Uridine-5'-diphospho-beta-L-arabinofuranose, a possible donor of L-arabinofuranose residues in plants, was synthesized. This compound, in the presence of UDP-galactopyranose mutase, underwent interconversion with UDP-beta-L-arabinopyranose that is a likely precursor of L-arabinofuranose in vivo. This result provided a working model for the biogenesis of arabinofuranose in plants.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Chromatography, High Pressure Liquid
Intramolecular Transferases / metabolism*
Plants / chemistry
Uridine Diphosphate Galactose / metabolism
Uridine Diphosphate Sugars / chemical synthesis
Uridine Diphosphate Sugars / metabolism*

Substances

Uridine Diphosphate Sugars
uridine diphosphate arabinose
Uridine Diphosphate Galactose
Intramolecular Transferases

Grants and funding

GM54346/GM/NIGMS NIH HHS/United States