4,5-Dihydroisoxazoles: testing of antimicrobial activity

I Zadrozna; J Kurkowska; H Kruszewska; I Makuch

doi:10.1016/s0014-827x(00)00066-5

4,5-Dihydroisoxazoles: testing of antimicrobial activity

Farmaco. 2000 Jun-Jul;55(6-7):499-501. doi: 10.1016/s0014-827x(00)00066-5.

Authors

I Zadrozna¹, J Kurkowska, H Kruszewska, I Makuch

Affiliation

¹ Warsaw University of Technology, Faculty of Chemistry, Division of Organic Chemistry, Poland. zarodna@ch.pw.edu.pl

PMID: 11204753
DOI: 10.1016/s0014-827x(00)00066-5

Abstract

In the 1,3-dipolar cycloaddition of aliphatic nitrile to selected olefins, a series of 4,5-dihydroisoxazoles substituted with various functional groups, ester, carbonyl and ethereal, was obtained. These compounds were investigated for antimicrobial activity on chosen strains.

MeSH terms

Anti-Bacterial Agents
Anti-Infective Agents / chemical synthesis*
Anti-Infective Agents / pharmacology
Candida albicans / drug effects
Escherichia coli / drug effects
Microbial Sensitivity Tests
Oxazoles / chemical synthesis*
Oxazoles / pharmacology*
Staphylococcus aureus / drug effects
Stereoisomerism

Substances

Anti-Bacterial Agents
Anti-Infective Agents
Oxazoles