A 79-year-old male patient with peritoneal recurrence of gastric cancer 1 year and 7 months after radical operation was treated by oral administration of 5'-DFUR. After the beginning of oral administration of 5'-DFUR, he survived 2 years and 7 months with a good performance status and without any adverse effects. A very limited number of cases with long survival by the oral administration of 5'-DFUR after peritoneal recurrence of gastric cancer have been reported. Of a total of 653.0 g of 5'-DFUR administrated, 436.8 g (66.9%) were given in a protocol consisting of daily oral 1,600 mg of 5'-DFUR for 7 consecutive days and 7 drug free days. This high-dose (1,053 mg/m2/day) and intermittent method of 5'-DFUR administration might have contributed to the long survival and good performance status of this patient.