Effect of Semax on homeostasis of gastric mucosa in albino rats

S E Zhuikova; E A Smirnova; Z V Bakaeva; G E Samonina; I P Ashmarin

Effect of Semax on homeostasis of gastric mucosa in albino rats

Bull Exp Biol Med. 2000 Sep;130(9):871-3.

Authors

S E Zhuikova¹, E A Smirnova, Z V Bakaeva, G E Samonina, I P Ashmarin

Affiliation

¹ Department of Human and Animal Physiology, Biological Faculty of M. V. Lomonosov Moscow State University.

PMID: 11177268

Abstract

The ACTH(4-7)analogue Semax administered intraperitoneally in a dose of 50 microg/kg 1 h before exposure to ulcerogenic factors (ethanol, water immersion immobilization stress) protected gastric mucosa from damage. Postoperative treatment with Semax for 5 days after application of glacial acetic acid on the mucosa prevented acetic acid-induced ulcers and promoted their healing. The antiulcer effects of Semax in the studied dose were comparable with those of tripeptide Pro-Gly-Pro in a dose of 1 mg/kg.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adrenocorticotropic Hormone / analogs & derivatives
Adrenocorticotropic Hormone / pharmacology*
Adrenocorticotropic Hormone / therapeutic use
Animals
Gastric Mucosa / drug effects*
Gastric Mucosa / physiopathology
Homeostasis / drug effects
Neuroprotective Agents / pharmacology*
Peptide Fragments / pharmacology*
Peptide Fragments / therapeutic use
Rats
Stomach Ulcer / drug therapy*
Stomach Ulcer / physiopathology

Substances

Neuroprotective Agents
Peptide Fragments
ACTH (4-7), Pro-Gly-Pro-
Adrenocorticotropic Hormone