Exercise echocardiography is a widely used modality for the noninvasive assessment of coronary artery disease. However, limitations exist inherent to the acquisition of transthoracic echocardiographic images. Although transesophageal echocardiography has been used during pacing or pharmacological stress, its use during exercise stress testing has not been clinically feasible due to the large probe size. Recently, a miniaturized transesophageal probe was developed, and we sought to test the feasibility of using this probe during graded treadmill exercise testing. Normal subjects were studied with transnasal echocardiography during upright treadmill exercise testing. The transnasal probe was passed in 13 of the 15 subjects. Excellent-quality monoplane two-dimensional echocardiographic images were obtained in all patients in the upright position. During exercise treadmill testing, high quality clinically useful echocardiographic images of the left ventricular short axis could be maintained. We conclude that transnasal transesophageal stress echocardiography may offer a new modality for the exercise assessment of ischemic heart disease.