The title compound, [CuCl2(C3H7N3O2)2], is a new copper(II) complex with glycocyamine [(diaminomethyleneamino)acetic acid], the first complex ever reported with this organic molecule. It is composed of discrete centrosymmetric coordinated CuII monomers, the Cu atoms being located at inversion centers. Each metal ion is square-planar coordinated by two Cl atoms and two glycocyamine O atoms. The coordinating glycocyamine molecule exists as a zwitterion, the H atom from the carboxyl group being transferred to the guanidinium group. A three-dimensional network of hydrogen bonds links the monomers and stabilizes the structure.