Involvement of GABA(A) receptor in modulation of jaw muscle activity evoked by mustard oil application to the rat temporomandibular joint

Brain Res. 2001 Feb 16;892(1):198-202. doi: 10.1016/s0006-8993(00)03283-2.

Abstract

The effect of intrathecal administration of the GABA(A) receptor antagonist bicuculline methylbromide on jaw muscle electromyographic (EMG) activity evoked by mustard oil injection into the rat temporomandibular joint was studied. Bicuculline given prior to mustard oil augmented the EMG activity evoked by mustard oil, and "rekindling" of EMG activity was induced by bicuculline given 30 min after mustard oil. These results suggest that central GABA(A) receptors modulate reflex responses to noxious craniofacial stimuli.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bicuculline / administration & dosage
  • Bicuculline / analogs & derivatives*
  • Bicuculline / pharmacology*
  • Drug Administration Schedule
  • Electromyography / drug effects
  • Functional Laterality
  • GABA Antagonists / administration & dosage
  • GABA Antagonists / pharmacology
  • Injections, Spinal
  • Male
  • Masseter Muscle / drug effects
  • Masseter Muscle / innervation
  • Masseter Muscle / physiology
  • Masticatory Muscles / drug effects
  • Masticatory Muscles / innervation
  • Masticatory Muscles / physiology*
  • Microinjections
  • Mustard Plant
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Oils
  • Plants, Medicinal
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, GABA-A / drug effects
  • Receptors, GABA-A / physiology*
  • Temporomandibular Joint / drug effects
  • Temporomandibular Joint / physiology*

Substances

  • GABA Antagonists
  • Plant Extracts
  • Plant Oils
  • Receptors, GABA-A
  • bicuculline methobromide
  • mustard oil
  • Bicuculline