Circumdatin G, a new alkaloid from the fungus Aspergillus ochraceus

J Dai; B K Carté; P J Sidebottom; A L Sek Yew; S Ng; Y Huang; M S Butler

doi:10.1021/np000381u

Circumdatin G, a new alkaloid from the fungus Aspergillus ochraceus

J Nat Prod. 2001 Jan;64(1):125-6. doi: 10.1021/np000381u.

Authors

J Dai¹, B K Carté, P J Sidebottom, A L Sek Yew, S Ng, Y Huang, M S Butler

Affiliation

¹ Centre for Natural Product Research, Institute of Molecular and Cell Biology, 59A Science Park Drive, The Fleming, Singapore Science Park, Singapore.

PMID: 11170686
DOI: 10.1021/np000381u

Abstract

The crude extract of the broth of Aspergillus ochraceus was found to inhibit the final stage of polyprotein processing during hepatitis C virus replication. Bioassay-guided fractionation led to the isolation of the known compound mellein as the active component of the extract. Also isolated were circumdatin F and a new alkaloid, circumdatin G. The structure of circumdatin G was determined by spectroscopic analysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification*
Alkaloids / pharmacology
Antiviral Agents / chemistry
Antiviral Agents / isolation & purification*
Antiviral Agents / pharmacology
Aspergillus ochraceus / chemistry*
Fermentation
Hepacivirus / drug effects
Hepacivirus / enzymology
Isocoumarins
Magnetic Resonance Spectroscopy
Ochratoxins / chemistry
Ochratoxins / isolation & purification*
Ochratoxins / pharmacology
Protease Inhibitors / chemistry
Protease Inhibitors / isolation & purification
Protease Inhibitors / pharmacology
Virus Replication / drug effects

Substances

Alkaloids
Antiviral Agents
Isocoumarins
Ochratoxins
Protease Inhibitors
circumdatin F
circumdatin G
ochracin