Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae

M Kuroda; Y Mimaki; A Yokosuka; Y Sashida; J A Beutler

doi:10.1021/np0003084

Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae

J Nat Prod. 2001 Jan;64(1):88-91. doi: 10.1021/np0003084.

Authors

M Kuroda¹, Y Mimaki, A Yokosuka, Y Sashida, J A Beutler

Affiliation

¹ Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan.

PMID: 11170674
DOI: 10.1021/np0003084

Abstract

Further phytochemical analysis of the bulbs of Ornithogalum saundersiae has yielded two new cytotoxic cholestane triglycosides (1 and 2). The structures of these compounds were determined by spectroscopic analysis, including 2D NMR spectroscopic data, and the results of hydrolytic cleavage. Compounds 1 and 2 and several analogues were evaluated for their cytotoxicity against HL-60 cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Cholestanes / isolation & purification*
Cholestanes / pharmacology
Drug Screening Assays, Antitumor
Glycosides / isolation & purification*
Glycosides / pharmacology
HL-60 Cells
Humans
Hydrolysis
Liliaceae / chemistry*
Plant Roots / chemistry*
Plants, Medicinal / chemistry*
Spectrometry, Mass, Fast Atom Bombardment
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Cholestanes
Glycosides