Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230

I F Pelyvás; Z G Tóth; G Vereb; A Balla; E Kovács; A Gorzsás; F Sztaricskai; P Gergely

doi:10.1021/jm001081c

Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230

J Med Chem. 2001 Feb 15;44(4):627-32. doi: 10.1021/jm001081c.

Authors

I F Pelyvás¹, Z G Tóth, G Vereb, A Balla, E Kovács, A Gorzsás, F Sztaricskai, P Gergely

Affiliation

¹ Research Group of Antibiotics of the Hungarian Academy of Sciences, University of Debrecen, P.O. Box 70, Debrecen H-4010, Hungary. antibiotics@tigris.klte.hu

PMID: 11170653
DOI: 10.1021/jm001081c

Abstract

The synthesis, chemical derivatization, and investigation of the inhibitory properties of novel cyclitol derivatives on the phosphatidylinositol 4-kinase enzymes PI4K55 and PI4K230 involved in the phosphatidylinositol cycle are reported. Some of the prepared cyclitol derivatives (i.e. 9, 11, 12, and 14) proved to be very powerful and specific irreversible inhibitors of PI4K230 at or below a concentration of 1 mM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cattle
Cyclohexanones / chemical synthesis*
Cyclohexanones / chemistry
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / chemistry
Isoenzymes / antagonists & inhibitors
Phosphotransferases (Alcohol Group Acceptor) / antagonists & inhibitors*
Structure-Activity Relationship
Sugar Alcohols / chemical synthesis*
Sugar Alcohols / chemistry

Substances

Cyclohexanones
Enzyme Inhibitors
Isoenzymes
Sugar Alcohols
Phosphotransferases (Alcohol Group Acceptor)
1-phosphatidylinositol-4-phosphate 5-kinase