Pleomorphic xanthoastrocytoma: report of a case diagnosed by intraoperative cytopathological examination

Diagn Cytopathol. 2001 Feb;24(2):120-2. doi: 10.1002/1097-0339(200102)24:2<120::aid-dc1022>3.0.co;2-5.

Abstract

The authors present an unusual case of a 13-yr-old boy with a 3-mo history of seizures. A CT scan showed a contrast-enhancing mass located in the left temporal lobe. The patient underwent a stereotatic-guided craniotomy; intraoperative cytological diagnosis was performed by the smear technique, showing a pleomorphic xanthoastrocytoma. The tumor was totally resected. Definitive diagnosis was established by examination of paraffin-embedded material. Six months after the surgical intervention, the patient is doing well, with no radiological evidence of recurrence. The cytological differential diagnosis of giant cell lesions of the central nervous system is emphasized.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anticonvulsants / therapeutic use
  • Astrocytoma / diagnosis*
  • Astrocytoma / surgery
  • Astrocytoma / therapy
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / surgery
  • Brain Neoplasms / therapy
  • Carbamazepine / therapeutic use
  • Cytodiagnosis
  • Giant Cells / chemistry
  • Giant Cells / pathology
  • Glial Fibrillary Acidic Protein / analysis
  • Humans
  • Immunohistochemistry
  • Intraoperative Period
  • Male
  • Proliferating Cell Nuclear Antigen / metabolism

Substances

  • Anticonvulsants
  • Glial Fibrillary Acidic Protein
  • Proliferating Cell Nuclear Antigen
  • Carbamazepine