Osseointegrated implants as anchors for various prosthetic reconstructions have become a predictable treatment alternative. It was expected that implants required submucosal placement during the healing period for successful tissue integration. However, it has been demonstrated that healing and long-term health of implants could be achieved with equal predictability in a 1-stage, non-submerged approach. This prospective 5-year study not only calculates implant success by life table analysis, but also evaluates the correlation between observed bone level changes with clinical parameters as measured by suppuration, plaque indices, bleeding indices, probing depth, attachment level and mobility. A total of 112 ITI dental implants were inserted in different areas of the jaws. Clinical and radiographic parameters were evaluated annually for 5 years, whereas a portion of the study group for which 6-year evaluations were available were included in the life-table analysis. The overall success rate after 5 years in service was 99.1%, while after 6 years it was reduced to 95.5% due to the fracture of 3 implants in 1 patient. The mean crestal bone loss experienced during the first year was 0.6 mm followed by an annual yearly loss of approximately 0.05 mm. No significant differences could be found between the amount of bone loss measured at each of the yearly follow-up visits. This suggests that statistically the followed implants did not show any radiographically measurable bone loss following the initial period of bone loss associated with implant placement and osseointegration. Low levels of correlation between the individual and cumulative clinical parameters with radiographically measured bone loss suggests that these parameters are of limited clinical value in assessing and predicting future peri-implant bone loss.