Abstract
Several vertebrate genes of the Hairy/Enhancer-of-split (HES) family are involved in paraxial mesoderm segmentation and intersomitic boundary establishment/maintenance. Here, we show that the zebrafish hairy-related gene, her6, highly homologous to the mammalian and chicken HES-1 genes, is expressed in the posterior part of each segmented somite and in stripes in the anterior presomitic mesoderm (PSM), and also in a dynamic, segmentally restricted pattern during hindbrain segmentation, with all rhombomeres expressing her6 at different time points and at different levels.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Basic Helix-Loop-Helix Transcription Factors
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Brain / embryology*
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Chickens
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Cloning, Molecular
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DNA, Complementary / metabolism
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Embryo, Nonmammalian
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Humans
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Mesoderm / metabolism
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Mice
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Molecular Sequence Data
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Rats
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Repressor Proteins / biosynthesis*
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Repressor Proteins / genetics*
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Rhombencephalon / metabolism
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Sequence Homology, Amino Acid
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Somites / metabolism*
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Time Factors
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Transcription Factors / biosynthesis*
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Transcription Factors / genetics*
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Xenopus
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Zebrafish
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Zebrafish Proteins*
Substances
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Basic Helix-Loop-Helix Transcription Factors
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DNA, Complementary
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Her6 protein, zebrafish
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Repressor Proteins
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Transcription Factors
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Zebrafish Proteins