Macrolide resistance in Peptostreptococcus spp. mediated by ermTR: possible source of macrolide-lincosamide-streptogramin B resistance in Streptococcus pyogenes

M Reig; J Galan; F Baquero; J C Perez-Diaz

doi:10.1128/AAC.45.2.630-632.2001

Macrolide resistance in Peptostreptococcus spp. mediated by ermTR: possible source of macrolide-lincosamide-streptogramin B resistance in Streptococcus pyogenes

Antimicrob Agents Chemother. 2001 Feb;45(2):630-2. doi: 10.1128/AAC.45.2.630-632.2001.

Authors

M Reig¹, J Galan, F Baquero, J C Perez-Diaz

Affiliation

¹ Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSALUD), 28034 Madrid, Spain. mreig@hrc.insalud.es

Abstract

Eighty percent (21 of 26) of macrolide-resistant Peptostreptococcus strains studied harbored the ermTR gene. This methyltransferase gene is also the most frequently found gene among macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes strains. Transfer of the ermTR gene from Peptostreptococcus magnus to macrolide-susceptible S. pyogenes strains indicates that this resistance determinant may circulate among gram-positive aerobic and anaerobic species of the oropharyngeal bacterial flora.

MeSH terms

Anti-Bacterial Agents / pharmacology*
Bacterial Proteins*
Conjugation, Genetic / genetics
Drug Resistance, Microbial
Electrophoresis, Agar Gel
Genes, Bacterial / genetics*
Humans
Lincosamides
Macrolides*
Methyltransferases / genetics*
Peptostreptococcus / drug effects*
Peptostreptococcus / genetics*
Reverse Transcriptase Polymerase Chain Reaction
Streptococcal Infections / microbiology
Streptococcus pyogenes / drug effects*
Streptococcus pyogenes / genetics*
Virginiamycin / pharmacology*

Substances

Anti-Bacterial Agents
Bacterial Proteins
Lincosamides
Macrolides
Virginiamycin
ErmTR protein, bacteria
Methyltransferases