Emergence of multiple human cytomegalovirus ganciclovir-resistant mutants with deletions and substitutions within the UL97 gene in a patient with severe combined immunodeficiency

Antimicrob Agents Chemother. 2001 Feb;45(2):593-5. doi: 10.1128/AAC.45.2.593-595.2001.

Abstract

Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. These unique findings may be related to the nature of the immunodeficiency in the SCID patient.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Antiviral Agents / pharmacology*
  • Cytomegalovirus / drug effects*
  • Cytomegalovirus / genetics*
  • Drug Resistance, Microbial
  • Female
  • Ganciclovir / pharmacology*
  • Gene Deletion
  • Genes, Bacterial / genetics
  • Humans
  • Infant
  • Mutation / genetics
  • Severe Combined Immunodeficiency / virology*
  • Viral Plaque Assay

Substances

  • Antiviral Agents
  • Ganciclovir