Abstract
Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. These unique findings may be related to the nature of the immunodeficiency in the SCID patient.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Substitution
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Antiviral Agents / pharmacology*
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Cytomegalovirus / drug effects*
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Cytomegalovirus / genetics*
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Drug Resistance, Microbial
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Female
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Ganciclovir / pharmacology*
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Gene Deletion
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Genes, Bacterial / genetics
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Humans
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Infant
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Mutation / genetics
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Severe Combined Immunodeficiency / virology*
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Viral Plaque Assay
Substances
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Antiviral Agents
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Ganciclovir