Overexpression of the response regulator evgA of the two-component signal transduction system modulates multidrug resistance conferred by multidrug resistance transporters

K Nishino; A Yamaguchi

doi:10.1128/JB.183.4.1455-1458.2001

Overexpression of the response regulator evgA of the two-component signal transduction system modulates multidrug resistance conferred by multidrug resistance transporters

J Bacteriol. 2001 Feb;183(4):1455-8. doi: 10.1128/JB.183.4.1455-1458.2001.

Authors

K Nishino¹, A Yamaguchi

Affiliation

¹ Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan.

Abstract

Overexpression of evgA, a response regulator of a two-component system, increased multidrug efflux in Escherichia coli. Since overexpression of the emrKY operon, which is controlled by evgAS, could account only for deoxycholate resistance, the evgAS locus apparently controls expression of at least one other multidrug efflux operon.

MeSH terms

ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics*
ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism*
Amino Acid Sequence
Bacterial Proteins / biosynthesis*
Biological Transport
Doxorubicin / metabolism
Drug Resistance, Microbial*
Drug Resistance, Multiple / genetics*
Escherichia coli
Escherichia coli Proteins*
Gene Expression Regulation, Bacterial
Microbial Sensitivity Tests
Molecular Sequence Data
Rhodamines / metabolism
Signal Transduction
Transcription Factors / biosynthesis*

Substances

ATP Binding Cassette Transporter, Subfamily B, Member 1
Bacterial Proteins
BvgA protein, Bacteria
Escherichia coli Proteins
EvgA protein, E coli
Rhodamines
Transcription Factors
rhodamine 6G
Doxorubicin