Synthesis and antimycobacterial activity of some 4H-1,2,4-triazin-5-one derivatives

M G Mamolo; V Falagiani; D Zampieri; L Vio; E Banfi

doi:10.1016/s0014-827x(00)00074-4

Synthesis and antimycobacterial activity of some 4H-1,2,4-triazin-5-one derivatives

Farmaco. 2000 Sep-Oct;55(9-10):590-5. doi: 10.1016/s0014-827x(00)00074-4.

Authors

M G Mamolo¹, V Falagiani, D Zampieri, L Vio, E Banfi

Affiliation

¹ Dipartimento di Scienze Farmaceutiche, Università di Trieste, Italy. mamolo@univ.trieste.it

PMID: 11152239
DOI: 10.1016/s0014-827x(00)00074-4

Abstract

6-[(Arylmethylenamino)carbonyl]-3-(pyridin-2-yl)-4H-1,2,4-triazin-5-one derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed interesting activity against a strain of Mycobacterium tuberculosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / chemical synthesis
Antitubercular Agents / chemistry
Antitubercular Agents / pharmacology*
Molecular Structure
Mycobacterium avium / drug effects
Mycobacterium tuberculosis / drug effects
Triazines / chemical synthesis
Triazines / chemistry
Triazines / pharmacology*

Substances

Antitubercular Agents
Triazines