A new inhibitor of 5'-hydroxyaverantin dehydrogenase, an enzyme involved in aflatoxin biosynthesis, from Trichoderma hamatum

E Sakuno; K Yabe; T Hamasaki; H Nakajima

doi:10.1021/np000194w

A new inhibitor of 5'-hydroxyaverantin dehydrogenase, an enzyme involved in aflatoxin biosynthesis, from Trichoderma hamatum

J Nat Prod. 2000 Dec;63(12):1677-8. doi: 10.1021/np000194w.

Authors

E Sakuno¹, K Yabe, T Hamasaki, H Nakajima

Affiliation

¹ Department of Agricultural Chemistry, Faculty of Agriculture, Tottori University, Koyama, Tottori 680-8553, Japan.

PMID: 11141114
DOI: 10.1021/np000194w

Abstract

Screening for inhibitors of 5'-hydroxyaverantin dehydrogenase, an enzyme involved in aflatoxin biosynthesis, resulted in the isolation of a new metabolite (1) from Trichoderma hamatum. On the basis of spectroscopic data, 1 was determined to be 4, 6-dihydroxy-5-methoxy-6a-methylcyclohexa[de]indano[7, 6-e]cyclopenta[c]2H-pyran-1,9-dione.

MeSH terms

Aflatoxins / biosynthesis*
Aflatoxins / chemistry
Aflatoxins / isolation & purification*
Aflatoxins / pharmacology
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification*
Enzyme Inhibitors / pharmacology
Ketone Oxidoreductases / antagonists & inhibitors*
Ketone Oxidoreductases / metabolism
Pyrans / chemistry
Pyrans / isolation & purification*
Pyrans / pharmacology
Trichoderma / chemistry*

Substances

4, 6-dihydroxy-5-methoxy-6a-methylcyclohexa(de)indano(7, 6-e)cyclopenta(c)2H-pyran-1,9-dione
Aflatoxins
Enzyme Inhibitors
Pyrans
5'-hydroxyaverantin dehydrogenase
Ketone Oxidoreductases