Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex

A K Bence; D T Rogers; D R Worthen; M Fu; J M Littleton; P A Crooks

doi:10.1016/s0960-894x(00)00530-8

Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex

Bioorg Med Chem Lett. 2000 Dec 4;10(23):2621-3. doi: 10.1016/s0960-894x(00)00530-8.

Authors

A K Bence¹, D T Rogers, D R Worthen, M Fu, J M Littleton, P A Crooks

Affiliation

¹ Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536, USA.

PMID: 11128637
DOI: 10.1016/s0960-894x(00)00530-8

Abstract

As part of a drug discovery program using high-throughput radioligand-binding assays, aminoanthraquinones were identified as potential modulators of N-methyl-D-aspartate (NMDA) receptor function. Aminoanthraquinones may represent a novel class of polyamine binding site ligands with a unique pharmacophore and may facilitate the rational design of novel NMDA-receptor modulators.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Anthraquinones / chemistry
Anthraquinones / metabolism*
Binding Sites
Biogenic Polyamines
Dizocilpine Maleate / metabolism
Excitatory Amino Acid Antagonists / metabolism
Ligands
Receptors, N-Methyl-D-Aspartate / metabolism*

Substances

Anthraquinones
Biogenic Polyamines
Excitatory Amino Acid Antagonists
Ligands
Receptors, N-Methyl-D-Aspartate
Dizocilpine Maleate

Grants and funding

AA12600/AA/NIAAA NIH HHS/United States