High-dose methotrexate is lethal to rats. Why give it to children?

Pediatr Hematol Oncol. 2000 Dec;17(8):609-13. doi: 10.1080/08880010050211312.
No abstract available

Publication types

  • Comment
  • Editorial

MeSH terms

  • Animals
  • Antimetabolites, Antineoplastic / administration & dosage*
  • Antimetabolites, Antineoplastic / therapeutic use
  • Antimetabolites, Antineoplastic / toxicity*
  • Child
  • Humans
  • Methotrexate / administration & dosage*
  • Methotrexate / therapeutic use
  • Methotrexate / toxicity*
  • Neoplasms / drug therapy*
  • Osteosarcoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Rats

Substances

  • Antimetabolites, Antineoplastic
  • Methotrexate