[Autonomic neuropathy in a diabetic population. Validity of cardiovascular tests and correlations with the complications]

Recenti Prog Med. 2000 Nov;91(11):562-6.
[Article in Italian]

Abstract

The disfunction of the autonomic system nervous is a frequent finding in diabetes mellitus. Among objective tests proposed for its diagnosis, those assessing cardiovascular reflexes (cardiovascular tests: CVTs) explore the autonomic functionality by means of a group of standardized manoeuvres of relatively easy execution that study the baroreceptorial reflex arc. In our study, CVTs were performed in a population of 207 diabetic patients with no symptoms of autonomic neuropathy. A computerized automatic system (Cardionomic) was utilized. CTVs included: Deep Breathing, Lying to Standing, Valsalva Manoeuvre, Orthostatic Hypotension, Standing to Lying and Cough Test. Diabetic patients were broken down in groups according to: a) age, b) HbA1c levels, c) disease duration. We have then compared the presence of diabetic complications between the group of diabetics positive for cardiovascular disautonomia (CVD+) with another group of diabetics who were negative for cardiovascular disautonomia (DCV-). Our results show a remarkable correlation between autonomic neuropathy and patients age, HbA1c levels and disease duration. Also they show a strong positive correlation between CDV+ and the severity of arteriopathy. We conclude that autonomic neuropathy may play an important role in the pathogenesis of diabetic arteriopathy.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Arteriosclerosis / diagnosis
  • Arteriosclerosis / etiology
  • Autonomic Nervous System Diseases / diagnosis*
  • Autonomic Nervous System Diseases / etiology
  • Diabetic Angiopathies / diagnosis
  • Diabetic Angiopathies / etiology
  • Diabetic Neuropathies / diagnosis*
  • Diabetic Neuropathies / etiology
  • Diagnosis, Computer-Assisted / methods
  • Diagnostic Techniques, Cardiovascular*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Sensitivity and Specificity