Prevalence and mechanisms of macrolide resistance in Streptococcus pyogenes in Santiago, Chile

E L Palavecino; I Riedel; X Berrios; S Bajaksouzian; D Johnson; E Kaplan; M R Jacobs

doi:10.1128/AAC.45.1.339-341.2001

Prevalence and mechanisms of macrolide resistance in Streptococcus pyogenes in Santiago, Chile

Antimicrob Agents Chemother. 2001 Jan;45(1):339-41. doi: 10.1128/AAC.45.1.339-341.2001.

Authors

E L Palavecino¹, I Riedel, X Berrios, S Bajaksouzian, D Johnson, E Kaplan, M R Jacobs

Affiliation

¹ Laboratory Services and Department of Public Health, Universidad Catolica, Santiago, Chile.

Abstract

Thirty-two macrolide-resistant Streptococcus pyogenes isolates were found among 594 clinical isolates collected from 1990 to 1998 in Santiago, Chile, for an overall prevalence of 7.2%. Among the 32 resistant isolates, 28 (87.5%) presented the M phenotype and 4 (12. 5%) presented the MLS(B) phenotype. Serotyping and pulsed-field gel electrophoresis analysis showed genetic diversity among the resistant isolates.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Chile / epidemiology
Clindamycin / pharmacology
Drug Resistance, Microbial
Electrophoresis, Gel, Pulsed-Field
Erythromycin / pharmacology
Microbial Sensitivity Tests
Phenotype
Reverse Transcriptase Polymerase Chain Reaction
Streptococcal Infections / epidemiology*
Streptococcal Infections / microbiology*
Streptococcus pyogenes / drug effects*
Streptococcus pyogenes / genetics

Substances

Anti-Bacterial Agents
Clindamycin
Erythromycin