Abstract
Streptococcus pneumoniae clinical isolate BM4455 was resistant to 16-membered macrolides and to streptogramins. This unusual resistance phenotype was due to an A(2062)C (Escherichia coli numbering) mutation in domain V of the four copies of 23S rRNA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology*
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Drug Resistance, Microbial
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Macrolides
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Microbial Sensitivity Tests
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Mutation / genetics
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Oligonucleotides / pharmacology
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Phenotype
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RNA, Ribosomal, 23S / genetics*
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Streptococcus pneumoniae / drug effects*
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Streptococcus pneumoniae / genetics*
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Virginiamycin / metabolism
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Virginiamycin / pharmacology*
Substances
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Anti-Bacterial Agents
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Macrolides
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Oligonucleotides
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RNA, Ribosomal, 23S
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Virginiamycin