Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae

Antimicrob Agents Chemother. 2001 Jan;45(1):319-23. doi: 10.1128/AAC.45.1.319-323.2001.

Abstract

Streptococcus pneumoniae clinical isolate BM4455 was resistant to 16-membered macrolides and to streptogramins. This unusual resistance phenotype was due to an A(2062)C (Escherichia coli numbering) mutation in domain V of the four copies of 23S rRNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / metabolism
  • Anti-Bacterial Agents / pharmacology*
  • Drug Resistance, Microbial
  • Macrolides
  • Microbial Sensitivity Tests
  • Mutation / genetics
  • Oligonucleotides / pharmacology
  • Phenotype
  • RNA, Ribosomal, 23S / genetics*
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pneumoniae / genetics*
  • Virginiamycin / metabolism
  • Virginiamycin / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Macrolides
  • Oligonucleotides
  • RNA, Ribosomal, 23S
  • Virginiamycin