Design and synthesis of novel [60]fullerene derivatives as potential HIV aspartic protease inhibitors

G L Marcorin; T Da Ros; S Castellano; G Stefancich; I Bonin; S Miertus; M Prato

doi:10.1021/ol000217y

Design and synthesis of novel [60]fullerene derivatives as potential HIV aspartic protease inhibitors

Org Lett. 2000 Dec 14;2(25):3955-8. doi: 10.1021/ol000217y.

Authors

G L Marcorin¹, T Da Ros, S Castellano, G Stefancich, I Bonin, S Miertus, M Prato

Affiliation

¹ Dipartimento di Scienze Farmaceutiche, Università di Trieste, Piazzale Europa, 1, 34127 Trieste, Italy.

PMID: 11112616
DOI: 10.1021/ol000217y

Abstract

[structure] Two water-soluble fullerene derivatives have been computer-designed and synthesized. They may exhibit interesting anti-HIV activity owing to the presence of two ammonium groups strategically located on the spheroid surface.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbon / chemistry*
Drug Design
Fullerenes*
HIV Protease Inhibitors / chemical synthesis*
Magnetic Resonance Spectroscopy
Models, Molecular

Substances

Fullerenes
HIV Protease Inhibitors
Carbon
fullerene C60