Epithelioid trophoblastic tumor metastatic to the vagina: an immunohistochemical and ultrastructural study

Int J Gynecol Pathol. 2000 Oct;19(4):381-6. doi: 10.1097/00004347-200010000-00015.

Abstract

We describe an epithelioid trophoblastic tumor (ETT) metastatic to the vagina in a 30-year-old Japanese woman. A polypoid tumor in the vaginal orifice was composed of nests of intermediate trophoblastic cells that showed a striking epithelioid appearance. In the hysterectomy specimen, a tumor infiltrated through the myometrium and showed histologic findings similar to those of the vaginal tumor. The tumor cells were positive for cytokeratin, inhibin-alpha, and melanoma cell adhesion molecule (Mel-CAM, CD146) but were only focally positive for human placental lactogen. Electron microscopic examination revealed bundles of well-developed, intermediate-type filaments surrounding the nuclei.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, CD*
  • Antigens, Surface / analysis
  • Biopsy
  • CD146 Antigen
  • Cell Nucleus / pathology
  • Cytoplasm / pathology
  • Epithelioid Cells / pathology*
  • Female
  • Humans
  • Immunohistochemistry
  • Inhibins / analysis
  • Intermediate Filaments / pathology
  • Keratins / analysis
  • Membrane Glycoproteins*
  • Microscopy, Electron
  • Myometrium / pathology
  • Neural Cell Adhesion Molecules*
  • Placental Lactogen / analysis
  • Pregnancy
  • Trophoblastic Neoplasms / chemistry
  • Trophoblastic Neoplasms / pathology
  • Trophoblastic Neoplasms / secondary*
  • Uterine Neoplasms*
  • Vaginal Neoplasms / chemistry
  • Vaginal Neoplasms / pathology
  • Vaginal Neoplasms / secondary*

Substances

  • Antigens, CD
  • Antigens, Surface
  • CD146 Antigen
  • MCAM protein, human
  • Membrane Glycoproteins
  • Neural Cell Adhesion Molecules
  • inhibin-alpha subunit
  • Inhibins
  • Keratins
  • Placental Lactogen