Abstract
We describe an epithelioid trophoblastic tumor (ETT) metastatic to the vagina in a 30-year-old Japanese woman. A polypoid tumor in the vaginal orifice was composed of nests of intermediate trophoblastic cells that showed a striking epithelioid appearance. In the hysterectomy specimen, a tumor infiltrated through the myometrium and showed histologic findings similar to those of the vaginal tumor. The tumor cells were positive for cytokeratin, inhibin-alpha, and melanoma cell adhesion molecule (Mel-CAM, CD146) but were only focally positive for human placental lactogen. Electron microscopic examination revealed bundles of well-developed, intermediate-type filaments surrounding the nuclei.
MeSH terms
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Adult
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Antigens, CD*
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Antigens, Surface / analysis
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Biopsy
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CD146 Antigen
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Cell Nucleus / pathology
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Cytoplasm / pathology
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Epithelioid Cells / pathology*
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Female
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Humans
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Immunohistochemistry
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Inhibins / analysis
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Intermediate Filaments / pathology
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Keratins / analysis
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Membrane Glycoproteins*
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Microscopy, Electron
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Myometrium / pathology
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Neural Cell Adhesion Molecules*
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Placental Lactogen / analysis
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Pregnancy
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Trophoblastic Neoplasms / chemistry
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Trophoblastic Neoplasms / pathology
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Trophoblastic Neoplasms / secondary*
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Uterine Neoplasms*
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Vaginal Neoplasms / chemistry
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Vaginal Neoplasms / pathology
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Vaginal Neoplasms / secondary*
Substances
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Antigens, CD
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Antigens, Surface
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CD146 Antigen
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MCAM protein, human
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Membrane Glycoproteins
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Neural Cell Adhesion Molecules
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inhibin-alpha subunit
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Inhibins
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Keratins
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Placental Lactogen