Determination of optical purity of phosphonic acid analogues of aromatic amino acids by capillary electrophoresis with alpha-cyclodextrin

P Dzygiel; E Rudzińska; P Wieczorek; P Kafarski

doi:10.1016/s0021-9673(00)00465-9

Determination of optical purity of phosphonic acid analogues of aromatic amino acids by capillary electrophoresis with alpha-cyclodextrin

J Chromatogr A. 2000 Oct 20;895(1-2):301-7. doi: 10.1016/s0021-9673(00)00465-9.

Authors

P Dzygiel¹, E Rudzińska, P Wieczorek, P Kafarski

Affiliation

¹ Institute of Chemistry, University of Opole, Poland.

PMID: 11105875
DOI: 10.1016/s0021-9673(00)00465-9

Abstract

A simple and efficient method for the determination of enantiomeric purity of structurally diverse phosphonic and phosphinic acid analogues of phenylalanine and phenylglycine using capillary electrophoresis is presented. These preliminary studies indicated that the enantiomer separation is strongly dependent on the structure of the aminophosphonic acid.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids / chemistry*
Cyclodextrins / chemistry*
Electrophoresis, Capillary / methods*
Organophosphonates / chemistry*
alpha-Cyclodextrins*

Substances

Amino Acids
Cyclodextrins
Organophosphonates
alpha-Cyclodextrins
alpha-cyclodextrin