A new antiplasmodial coumarin from Toddalia asiatica roots

H A Oketch-Rabah; J W Mwangi; J Lisgarten; E K Mberu

doi:10.1016/s0367-326x(00)00222-7

A new antiplasmodial coumarin from Toddalia asiatica roots

Fitoterapia. 2000 Dec;71(6):636-40. doi: 10.1016/s0367-326x(00)00222-7.

Authors

H A Oketch-Rabah¹, J W Mwangi, J Lisgarten, E K Mberu

Affiliation

¹ Department of Pharmacology and Pharmacognosy, Faculty of Pharmacy, College of Health Sciences, University of Nairobi, P.O. Box 19676, Nairobi, Kenya. heoketch@africaonline.co.ke

PMID: 11077169
DOI: 10.1016/s0367-326x(00)00222-7

Abstract

A new antiplasmodial coumarin, 5,7-dimethoxy-8-(3'-hydroxy-3'methyl-1'-butene)-coumarin (1), has been isolated from the roots of Toddalia asiatica. This finding supports the traditional use of this plant for the treatment of malaria.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antimalarials / chemistry*
Antimalarials / pharmacology
Coumarins / chemistry*
Coumarins / pharmacology
Humans
Medicine, African Traditional
Plant Extracts / chemistry*
Plant Extracts / pharmacology
Plant Roots / chemistry
Plants, Medicinal / chemistry*
Plasmodium falciparum / drug effects*

Substances

5,7-dimethoxy-8-(3'-hydroxy-3'-methyl-1'-butene)coumarin
Antimalarials
Coumarins
Plant Extracts
coumarin