A new indanone from the marine cyanobacterium Lyngbya majuscula that inhibits hypoxia-induced activation of the VEGF promoter in Hep3B cells

J Nat Prod. 2000 Oct;63(10):1431-3. doi: 10.1021/np000216e.

Abstract

A new indanone (1) has been isolated from the filamentous marine cyanobacterium Lyngbya majuscula, and its structure determined spectroscopically. Vascular endothelial growth factor (VEGF) is an important regulator of tumor angiogenesis. Compound 1 inhibits hypoxia-induced activation of the VEGF gene promoter in Hep3B human liver tumor cells, in vitro.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Hypoxia
  • Cyanobacteria / chemistry*
  • Endothelial Growth Factors / genetics
  • Gene Expression Regulation / drug effects*
  • Humans
  • Indans / chemistry*
  • Indans / isolation & purification
  • Indans / pharmacology
  • Lymphokines / genetics
  • Promoter Regions, Genetic
  • Tumor Cells, Cultured
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • Endothelial Growth Factors
  • Indans
  • Lymphokines
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • indacrinone