Synthesis of melithasterol A, a 5alpha,6alpha-epoxy-7alpha-hydroxy Delta(8)-steroid

P Ramesh; V L Reddy; N S Reddy; Y Venkateswarlu

doi:10.1021/np000095i

Synthesis of melithasterol A, a 5alpha,6alpha-epoxy-7alpha-hydroxy Delta(8)-steroid

J Nat Prod. 2000 Oct;63(10):1420-1. doi: 10.1021/np000095i.

Authors

P Ramesh¹, V L Reddy, N S Reddy, Y Venkateswarlu

Affiliation

¹ Natural Products Laboratory, Organic Division-I, Indian Institute of Chemical Technology, Hyderabad, 500 007, India.

PMID: 11076567
DOI: 10.1021/np000095i

Abstract

A short, first synthesis of melithasterol A (3) utilizing microwave irradiation-induced isomerization of 5alpha,8alpha-epidioxy steroid (1) as the key step has been achieved in 80% yield.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Sterols / chemical synthesis*

Substances

Sterols
melithasterol A