Stolonic acids A and B, new cytotoxic cyclic peroxides from an Indian Ocean ascidian Stolonica species

J Nat Prod. 2000 Oct;63(10):1411-3. doi: 10.1021/np000158x.

Abstract

Two new 3,6-epidioxy-7,10-tetrahydrofurano C(26) unsaturated fatty acids, stolonic acids A (1) and B (2), were isolated from a previously undescribed ascidian species, Stolonica sp. collected off the Maldive Islands in the Indian Ocean. The structures and relative stereochemistry of 1 and 2 were determined using conventional spectroscopic methods. Both compounds exhibited antiproliferative activity against selected human melanoma and ovarian tumor cell lines, with IC(50) values of approximately 0.05-0.1 microg/mL.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Drug Screening Assays, Antitumor
  • Fatty Acids, Unsaturated / chemistry
  • Fatty Acids, Unsaturated / isolation & purification*
  • Fatty Acids, Unsaturated / pharmacology
  • Furans / chemistry
  • Furans / isolation & purification*
  • Furans / pharmacology
  • Humans
  • Indian Ocean
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Peroxides / chemistry
  • Peroxides / isolation & purification*
  • Peroxides / pharmacology
  • Tumor Cells, Cultured
  • Urochordata / chemistry*

Substances

  • Antineoplastic Agents
  • Fatty Acids, Unsaturated
  • Furans
  • Peroxides
  • stolonic acid A
  • stolonic acid B