Ancistrolikokines A-C: new 5,8'-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko

G Bringmann; C Günther; W Saeb; J Mies; A Wickramasinghe; V Mudogo; R Brun

doi:10.1021/np000199t

Ancistrolikokines A-C: new 5,8'-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko

J Nat Prod. 2000 Oct;63(10):1333-7. doi: 10.1021/np000199t.

Authors

G Bringmann¹, C Günther, W Saeb, J Mies, A Wickramasinghe, V Mudogo, R Brun

Affiliation

¹ Institut für Organische Chemie der Universität, Am Hubland, D-97074 Würzburg, Germany, Department of Chemistry, University of Peradeniya, Peradeniya, Sri Lanka. bringham@chemie.uni-wuerzburg.de

PMID: 11076547
DOI: 10.1021/np000199t

Abstract

Three new naphthylisoquinoline alkaloids, ancistrolikokines A-C (1-3), have been isolated and structurally assigned from Ancistrocladus likoko, as well as the known compound korupensamine A (4). Their 5,8'-coupling hints at a close biogenetic relationship of A. likoko to other Central African Ancistrocladus species. Compounds 1-4 showed good to moderate antimalarial activities when evaluated in vitro against the NF54 and K1 strains of Plasmodium falciparum.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antimalarials / chemistry
Antimalarials / isolation & purification
Antimalarials / pharmacology
Democratic Republic of the Congo
Humans
In Vitro Techniques
Isoquinolines / chemistry
Isoquinolines / isolation & purification*
Isoquinolines / pharmacology
Magnetic Resonance Spectroscopy
Magnoliopsida / chemistry*
Molecular Structure
Naphthalenes / chemistry
Naphthalenes / isolation & purification*
Naphthalenes / pharmacology
Plasmodium falciparum / drug effects

Substances

Ancistrolikokine A
Ancistrolikokine B
Ancistrolikokine C
Antimalarials
Isoquinolines
Naphthalenes