Diabetes: the importance of the liver

Curr Biol. 2000 Oct 19;10(20):R736-8. doi: 10.1016/s0960-9822(00)00737-5.

Abstract

Insulin resistance, the hallmark of non-insulin dependent diabetes mellitus, is characterized by the failure of tissues to take up and store glucose in response to insulin. Two recent studies shed new light on the importance of insulin signalling in the liver and how this may become defective in diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus / metabolism
  • Diabetes Mellitus / physiopathology*
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Humans
  • Insulin / physiology*
  • Insulin Resistance
  • Liver / physiology
  • Liver / physiopathology*
  • Mice
  • Mice, Knockout
  • Receptor, Insulin / deficiency
  • Receptor, Insulin / genetics
  • Receptor, Insulin / physiology*

Substances

  • Insulin
  • Receptor, Insulin