Myorelaxant and antispasmodic effects of the essential oil of Alpinia speciosa on rat ileum

Phytother Res. 2000 Nov;14(7):549-51. doi: 10.1002/1099-1573(200011)14:7<549::aid-ptr623>3.0.co;2-t.

Abstract

The effects of the essential oil of Alpinia speciosa Schum (EOAS) on rat ileum were studied. EOAS (0.1-600 microg/mL) reversibly relaxed ileal basal tonus. Submaximal contractions induced by 60 mM KCl or acetylcholine were concentration dependently inhibited by EOAS with similar IC(50) values ( approximately 44 and 48 microg/mL, respectively). These results show that EOAS possesses both relaxant and antispasmodic actions in the ileum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ileum / drug effects*
  • Male
  • Muscle Contraction / drug effects
  • Muscle, Smooth / drug effects*
  • Oils, Volatile / pharmacology
  • Parasympatholytics / pharmacology*
  • Plant Oils / pharmacology*
  • Rats
  • Zingiberales*

Substances

  • Oils, Volatile
  • Parasympatholytics
  • Plant Oils