Synthesis of functionalized cannabinoids

J Org Chem. 2000 Oct 6;65(20):6576-82. doi: 10.1021/jo000716c.

Abstract

An effective synthesis of tricyclic, nonclassical cannabinoids has been developed on the basis of a cation-olefin cyclization that forms the two nonaromatic rings with the desired stereochemistry in a single step.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkenes
  • Animals
  • Brain / metabolism
  • Cannabinoids / chemical synthesis*
  • Cannabinoids / metabolism
  • Chromatography, High Pressure Liquid
  • Cyclization
  • Kinetics
  • Receptors, Cannabinoid
  • Receptors, Drug / metabolism
  • Spleen / metabolism
  • Stereoisomerism

Substances

  • Alkenes
  • Cannabinoids
  • Receptors, Cannabinoid
  • Receptors, Drug